Alprazolam Intensol official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
Each mL, for oral administration, contains 1 mg of alprazolam.
CNS Depression and Impaired Performance.
Alprazolam was compared to placebo in double blind clinical studies (doses up to 4 mg/day) in patients with a diagnosis of anxiety or anxiety with associated depressive symptomatology. Alprazolam was significantly better than placebo at each of the evaluation periods of these 4-week studies as judged by the following psychometric instruments: Physician’s Global Impressions, Hamilton Anxiety Rating Scale, Target Symptoms, Patient’s Global Impressions and Self-Rating Symptom Scale.
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Detailed dosage guidelines and administration information for Alprazolam Intensol (alprazolam). Includes dose adjustments, warnings and precautions.
In any case, reduction of dose must be undertaken under close supervision and must be gradual. If significant withdrawal symptoms develop, the previous dosing schedule should be reinstituted and, only after stabilization, should a less rapid schedule of discontinuation be attempted. In a controlled postmarketing discontinuation study of panic disorder patients which compared this recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome.
Consumer information about the medication ALPRAZOLAM CONCENTRATE SOLUTION - ORAL (Alprazolam Intensol), includes side effects, drug interactions.
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Alprazolam INTENSOL (Alprazolam) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Mix with liquid or semi-solid food. Adjust at intervals of at least 3–4 days. ≥18yrs: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly, debilitated, or advanced liver disease: initially 0.25mg 2–3 times daily. <18yrs: not recommended.
Only 4 drugs may be compared at once.
Generic Name and Formulations: Alprazolam 1mg; per 1mL; concentrated soln.
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See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine. Benzodiazepine.
Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.
Acute narrow angle glaucoma. Concomitant itraconazole, ketoconazole.
CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction. Soln—30mL (w. dropper).
Company: Roxane Laboratories, Inc. Anxiety.